Tamoxifen is frequently prescribed as treatment for estrogen-based cancers, but the Harvard Mental Health Letter reports that some antidepressants may interfere with the drug’s anti-cancer properties.
Three antidepressants—paroxetine (Paxil), fluoxetine (Prozac), and bupropion (Wellbutrin)—should be avoided while taking tamoxifen. These antidepressants are also used to treat hot flashes and aid with smoking cessation.
If you are taking both tamoxifen and one of these three drugs, please consult with your physician. The article notes that other antidepressants are less likely to interfere with tamoxifen. Better options for women taking tamoxifen include venlafaxine (Effexor), desvenlafaxine (Pristiq), and mirtazapine (Remeron).